Metformin vs. Semaglutide: Which Is Better for Type 2 Diabetes?
For millions living with type 2 diabetes, choosing the right medication is essential for long-term health. In 2025, two popular drugs—Metformin and Semaglutide—stand out as leading options. But how do they compare in blood sugar control, weight impact, and side effects?
Metformin has been the gold standard for decades. It’s affordable, well-studied, and typically prescribed as a first-line treatment. It works by reducing glucose production in the liver and increasing insulin sensitivity. Learn more in our Metformin guide.
Semaglutide, on the other hand, is a GLP-1 receptor agonist originally designed for diabetes but now also used for weight loss. It helps lower blood sugar by increasing insulin and slowing digestion. Learn how it helps in our semaglutide weight loss review and complete drug profile.
In terms of weight loss, Semaglutide offers a clear advantage. However, it is more expensive and can cause gastrointestinal side effects like nausea. Metformin is generally better tolerated and ideal for patients just starting treatment.
Which Should You Choose?
- Metformin: Best for affordability and mild cases
- Semaglutide: Better for patients needing weight loss support
- Consult a doctor: Always decide based on your medical profile