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| Comparing effectiveness of Metformin and Semaglutide for type 2 diabetes and weight loss in 2025 |
Metformin vs. Semaglutide: Which Is Better for Type 2 Diabetes?
In 2025, the landscape of type 2 diabetes treatment continues to evolve with newer and more targeted medications. While Metformin remains the global first-line therapy, newer GLP-1 agonists like Semaglutide have emerged as powerful contenders. But which one is better for glycemic control, weight loss, and long-term health?
🔹 Metformin: The Longstanding Standard
- Affordable and widely accessible
- Improves insulin sensitivity and reduces liver glucose production
- Minimal risk of hypoglycemia
🔹 Semaglutide: A Game-Changer
- GLP-1 receptor agonist with superior A1C reduction
- Promotes significant weight loss
- Weekly injection, well-tolerated with proper dose escalation
Clinical Comparison
- Efficacy: Semaglutide shows greater A1C and weight loss outcomes.
- Cost: Metformin is far more affordable.
- Safety: Both are safe with proper supervision, though Semaglutide may cause GI side effects.
Doctors often start with Metformin and add Semaglutide for patients who need further glycemic or weight control. In Dubai, both drugs are approved by the DHA and available with prescription.
Learn more about these medications in depth:
What is Semaglutide? Uses, Benefits, and Side EffectsMetformin: Dosage, Benefits, and Common Side Effects